Dimethylamine → HCID 58229873, compound

HRID 222007Notes

Reaction equation

HRID 222007 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[CH:17]=[CH:16][C:15]3=[N:18][N:19]=[C:20]([CH2:21]Cl)[N:14]3[C:5]2=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:23][NH:24][CH3:25]>>[Cl:1][C:2]1[N:3]=[C:4]2[CH:17]=[CH:16][C:15]3=[N:18][N:19]=[C:20]([CH2:21][N:24]([CH3:25])[CH3:23])[N:14]3[C:5]2=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 58229897HCID 58229897, compound

Product 1

HCID 58229873HCID 58229873, compound

Procedure

A mixture of 3-chloro-9-(chloromethyl)-2-phenyl[1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazine (10-2) (840 mg, 0.254 mmol) and dimethylamine (2M in THF, 5 mL, 10 mmol) was stirred at room temperature for 2 hours. The solvent was evaporated to give 1-(3-chloro-2-phenyl[1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazin-9-yl)-N,N-dimethylmethanamine (10-3).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-f380907a062742d39276524a0d263255
Source dataset
uspto-grants-2012_06
Patent number
US08207169B2

Reaction notes

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