反应详情

温度

120 °C

4-(3-Methoxy-phenyl)-piperidine (1.7 g) was dissolved in 48-% HBr (60 ml) and stirred at 120° C. under an Argon-atmosphere for 3 h. The excess of HBr was then evaporated and absolute ethanol added and evaporated. This procedure was repeated several times to yield dry crystals of 3-piperidin-4-yl-phenol×HBr (2.3 g). MS m/z (relative intensity, 70 eV) 177 (M+, bp), 176 (23), 91 (14), 57 (44), 56 (60).

1. customThe excess of HBr was then evaporated
2. additionabsolute ethanol added
3. customevaporated
4. customto yield
5. dry with materialdry crystals of 3-piperidin-4-yl-phenol×HBr (2.3 g)