4-Methoxy-alpha-toluenethiol → Ethyl 6-[(4-methoxybenzyl)sulfanyl]-1-cyclohexene-1-carboxylate

HRID 2220192Notes

Reaction equation

HRID 2220192 reaction equation
FC1C=C(F)C=CC=1N[S:10]([CH:13]1[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][CH2:16][CH2:15][CH2:14]1)(=O)=O.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32]S)=[CH:28][CH:27]=1>>[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][S:10][CH:13]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][CH2:16][CH2:15][CH2:14]2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 804074-Methoxy-alpha-toluenethiolHCID 9928140ethyl 6-[N-(2,4-difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate

Product 1

HCID 22026134Ethyl 6-[(4-methoxybenzyl)sulfanyl]-1-cyclohexene-1-carboxylateYield 95.6%

Procedure

In the same manner as in Reference Example 1, ethyl 6-[N-(2,4-difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate (1 g) and (4-methoxyphenyl)methanethiol (893 mg) were reacted to give ethyl 6-[(4-methoxybenzyl)-sulfanyl]-1-cyclohexene-1-carboxylate (848 mg) as a colorless oil.

Sources & evidence

ORD record
ord-2059ab0cc1d9426ea6c079d8eaa7392c
Source dataset
uspto-grants-2008_08
Patent number
US07417059B2

Reaction notes

Loading…