2-Methyl-5-nitroquinoline → 5-Quinolinamine, 2-methyl-

HRID 2220239ノート

反応式

HRID 2220239 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N+:12]([O-])=O)[N:3]=1.[H][H]>[Pd].C(O)(=O)C>[NH2:12][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]2

参加物

5

反応物 2

HCID 2948672-Methyl-5-nitroquinolineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 1486835-Quinolinamine, 2-methyl-収率 50.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

2-Methyl-5-nitroquinoline (25 g, 132.85 mmol) and palladium on carbon (2.5 g) in 8 ml of glacial acetic acid are stirred for 5½ hours in a hydrogen atmosphere at normal pressure. The catalyst is suctioned off and washed with ethyl acetate. The combined filtrates are concentrated by evaporation. Column chromatography of the residue on silica gel with dichloromethane-acetone yields 10.6 g of the product.

後処理

  1. washwashed with ethyl acetate
  2. concentrationThe combined filtrates are concentrated by evaporation

出典と根拠

ORDレコード
ord-95a717b61b4a425e9911bd9ad99529df
出典データセット
uspto-grants-2008_08
特許番号
US07417056B2

反応ノート

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