HRID2220244

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

HCID5033687

2,6-Dimethyl-quinolin-5-ylamine

C11H12N2

结构：CC(C)(CC(O)(C=O)C(F)(F)F)c1cc(F)cc2c1OCC2

HCID44184989

5-Fluoro-2,3-dihydro-α-hydroxy-γ,γ-dimethyl-α-(trifluoromethyl)-7-benzofuranbutanal

C15H16F4O3

结构：Cc1ccc2c(N=CC(O)(CC(C)(C)c3cc(F)cc4c3OCC4)C(F)(F)F)c(C)ccc2n1

HCID68855835

未命名化合物

PRODUCTS

生成物

HCID11561978

未命名化合物

PROCEDURE

实验过程

Analogously to Example 1, 4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal is converted with 5-amino-2,6-dimethylquinoline into 5-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylidenamino]-2,6-dimethylquinoline, which is reduced with sodium cyanoborohydride to the product.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-edc2a7c205424dbc9ee444705fcbebcd
来源数据集: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07417056B2
来源说明: uspto-grants-2008_08

反应 SMILES

FC1C=C(C(C)(C)CC(O)(C(F)(F)F)C=O)C2OCCC=2C=1.NC1C(C)=CC=C2C=1C=CC(C)=N2.[F:36][C:37]1[CH:38]=[C:39]([C:46]([CH3:69])([CH3:68])[CH2:47][C:48]([OH:67])([C:63]([F:66])([F:65])[F:64])[CH:49]=[N:50][C:51]2[C:60]([CH3:61])=[CH:59][CH:58]=[C:57]3[C:52]=2[CH:53]=[CH:54][C:55]([CH3:62])=[N:56]3)[C:40]2[O:44][CH2:43][CH2:42][C:41]=2[CH:45]=1.C([BH3-])#N.[Na+]>>[F:36][C:37]1[CH:38]=[C:39]([C:46]([CH3:69])([CH3:68])[CH2:47][C:48]([OH:67])([C:63]([F:64])([F:66])[F:65])[CH2:49][NH:50][C:51]2[C:60]([CH3:61])=[CH:59][CH:58]=[C:57]3[C:52]=2[CH:53]=[CH:54][C:55]([CH3:62])=[N:56]3)[C:40]2[O:44][CH2:43][CH2:42][C:41]=2[CH:45]=1