1-Amino-2-propanol → HCID 11989688, compound

HRID 2220285Notes

Reaction equation

HRID 2220285 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:16]=[CH:17][C:18]3[S:22][C:21]([C:23](O)=[O:24])=[C:20]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:19]=3[CH:32]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:33][CH2:34][CH:35]([OH:37])[CH3:36]>ClCCl.CO>[OH:37][CH:35]([CH3:36])[CH2:34][NH:33][C:23]([C:21]1[S:22][C:18]2[CH:17]=[CH:16][C:15]([NH:14][S:11]([C:8]3[CH:9]=[CH:10][C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:6][CH:7]=3)(=[O:12])=[O:13])=[CH:32][C:19]=2[C:20]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:24]

Participants

4

Reactant 2

HCID 41-Amino-2-propanolHCID 11989687HCID 11989687, compound

Product 1

HCID 11989688HCID 11989688, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

According to Step 1 after reaction of 5-(4-tert-Butylbenzenesulfonylamino)-3-phenyl-1-benzothiophene-2-carboxylic acid (155 mg, 0.33 mmol) with 1-amino-2-propanol (0.027 mL, 0.35 mmol) and subsequent chromatographic purification (silica gel, dichloromethane/methanol (0-10% methanol)), the desired compound is obtained at 17% yield (2 mg).

Sources & evidence

ORD record
ord-66028ef451c0488a90b2704c56d8f1cb
Source dataset
uspto-grants-2008_08
Patent number
US07417066B2

Reaction notes

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