Sodium Hydroxide → HCID 11989687, compound

HRID 2220288Notes

Reaction equation

HRID 2220288 reaction equation
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH:20]=[CH:19][C:18]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:27][CH:26]=3)(=[O:24])=[O:23])=[CH:17][C:9]=2[C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:5])C.[OH-].[Na+]>C(O)C.O>[C:31]([C:28]1[CH:27]=[CH:26][C:25]([S:22]([NH:21][C:18]2[CH:19]=[CH:20][C:8]3[S:7][C:6]([C:4]([OH:5])=[O:3])=[C:10]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)[C:9]=3[CH:17]=2)(=[O:23])=[O:24])=[CH:30][CH:29]=1)([CH3:34])([CH3:32])[CH3:33]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11989686HCID 11989686, compound

Product 1

HCID 11989687HCID 11989687, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

According to Step 5, after reaction of 5-(4-tert-Butylbenzenesulfonylamino)-3-phenyl-1-benzothiophene-2-carboxylic acid ethyl ester (1.24 g, 2.5 mmol) from Example 1d) with 1M sodium hydroxide solution in ethanol/water (2:1, 49 mL), the desired compound is obtained at quantitative yield (1.18 g).

Sources & evidence

ORD record
ord-4f2ea0e2651d4ea4a2297ff55341a28f
Source dataset
uspto-grants-2008_08
Patent number
US07417066B2

Reaction notes

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