Hydrochloric Acid → HCID 69103537, compound

Participants

Reaction Steps

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl](2-[3′-(3-methylbutyl)-4′-[[(methylsulfonyl)amino]carbonyl]-4-biphenylyl]ethyl]carbamate (380 mg) in ethyl acetate (2.0 ml) was added 4N hydrogen chloride in ethyl acetate (2.0 ml), and the mixture was stirred at room temperature for 12 hours. The resultant solid was collected by filtration and dried to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(3-methylbutyl)-N-(methylsulfonyl)-4-biphenylcarboxamide hydrochloride (80 mg).

Provenance & Evidence