Hydrochloric Acid → HCID 69103537, compound

HRID 2220377Notes

Reaction equation

HRID 2220377 reaction equation
[OH:1][C@H:2]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[CH2:3][N:4]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])=[O:27])=[C:22]([CH2:33][CH2:34][CH:35]([CH3:37])[CH3:36])[CH:21]=2)=[CH:16][CH:15]=1)C(=O)OC(C)(C)C.[ClH:44]>C(OCC)(=O)C>[ClH:44].[OH:1][C@H:2]([C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)[CH2:3][NH:4][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])=[O:27])=[C:22]([CH2:33][CH2:34][CH:35]([CH3:37])[CH3:36])[CH:21]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86598948HCID 86598948, compound

Product 1

HCID 69103537HCID 69103537, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl](2-[3′-(3-methylbutyl)-4′-[[(methylsulfonyl)amino]carbonyl]-4-biphenylyl]ethyl]carbamate (380 mg) in ethyl acetate (2.0 ml) was added 4N hydrogen chloride in ethyl acetate (2.0 ml), and the mixture was stirred at room temperature for 12 hours. The resultant solid was collected by filtration and dried to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(3-methylbutyl)-N-(methylsulfonyl)-4-biphenylcarboxamide hydrochloride (80 mg).

Workup

  1. filtrationThe resultant solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-b38f834074bb4f4496c3364276370b04
Source dataset
uspto-grants-2008_08
Patent number
US07417060B2

Reaction notes

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