Hydrochloric Acid → HCID 42639312, compound

HRID 2220381Notes

Reaction equation

HRID 2220381 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][N:29]([CH2:37][C@H:38]([OH:45])[C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=4)C(=O)OC(C)(C)C)=[CH:23][CH:22]=3)[CH:11]=[CH:12][C:13]=2[C:14]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[O:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:46]>O1CCOCC1>[ClH:46].[CH:1]1([O:7][C:8]2[CH:9]=[C:10]([C:21]3[CH:22]=[CH:23][C:24]([CH2:27][CH2:28][NH:29][CH2:37][C@H:38]([OH:45])[C:39]4[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=4)=[CH:25][CH:26]=3)[CH:11]=[CH:12][C:13]=2[C:14]([NH:16][S:17]([CH3:20])(=[O:18])=[O:19])=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 42639804HCID 42639804, compound

Product 1

HCID 42639312HCID 42639312, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl [2-[3′-(cyclohexyloxy)-4′-[[(methylsulfonyl)amino]carbonyl]-4-biphenylyl]ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (89 mg) in 1,4-dioxane (2 ml) was added 4N hydrogen chloride solution in 1,4-dioxane (4 ml) at room temperature and the mixture was stirred at the same temperature for 2 hours. The mixture was evaporated under reduced pressure to give 3-(cyclohexyloxy)-4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-N-(methylsulfonyl)-4-biphenylcarboxamide hydrochloride (76 mg).

Workup

  1. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8bae1a05186d4de2a00bda66f76b258a
Source dataset
uspto-grants-2008_08
Patent number
US07417060B2

Reaction notes

Loading…