Hydrogen chloride-ethyl acetate → HCID 69102992, compound

Participants

Reaction Steps

To a solution of tert-butyl [2-[3′-(isopropylamino)-4′-[[(methylsulfonyl)amino]carbonyl]-4-biphenylyl]ethyl]-carbamate (411 mg) in ethyl acetate (2 ml) was added hydrogen chloride ethyl acetate solution (4N, 2 ml) and stirred at room temperature overnight. The reaction mixture was evaporated and the residue was pulverized with diisopropyl ether. The resulting solid was collected by filtration and dried to give 4′-(2-aminoethyl)-3-(isopropylamino)-N-(methylsulfonyl)-4-biphenylcarboxamide dihydrochloride (281 mg).

Provenance & Evidence