Hydrogen chloride-ethyl acetate → HCID 69102992, compound

HRID 2220401Notes

Reaction equation

HRID 2220401 reaction equation
[CH:1]([NH:4][C:5]1[CH:6]=[C:7]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][NH:26]C(=O)OC(C)(C)C)=[CH:20][CH:19]=2)[CH:8]=[CH:9][C:10]=1[C:11]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[O:12])([CH3:3])[CH3:2].C(OC(=O)C)C.[ClH:40]>C(OCC)(=O)C>[ClH:40].[ClH:40].[NH2:26][CH2:25][CH2:24][C:21]1[CH:22]=[CH:23][C:18]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[O:12])=[C:5]([NH:4][CH:1]([CH3:3])[CH3:2])[CH:6]=2)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86598951HCID 86598951, compound

Product 1

HCID 69102992HCID 69102992, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl [2-[3′-(isopropylamino)-4′-[[(methylsulfonyl)amino]carbonyl]-4-biphenylyl]ethyl]-carbamate (411 mg) in ethyl acetate (2 ml) was added hydrogen chloride ethyl acetate solution (4N, 2 ml) and stirred at room temperature overnight. The reaction mixture was evaporated and the residue was pulverized with diisopropyl ether. The resulting solid was collected by filtration and dried to give 4′-(2-aminoethyl)-3-(isopropylamino)-N-(methylsulfonyl)-4-biphenylcarboxamide dihydrochloride (281 mg).

Workup

  1. customThe reaction mixture was evaporated
  2. filtrationThe resulting solid was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-437b58b57d7b4430bba776c20a9bae4a
Source dataset
uspto-grants-2008_08
Patent number
US07417060B2

Reaction notes

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