HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → Methyl 4'-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Methyl 4'-(2-hydroxyethoxy)-3-(isopropylthio)-4-biphenylcarboxylate | HCID 69102146 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4'-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate | HCID 69103348 | 96.9% |
Reaction Steps
To a solution of methyl 4′-(2-hydroxyethoxy)-3-(isopropylthio)-4-biphenylcarboxylate (124 mg) and tetrabromomethane (285 mg) in tetrahydrofuran (1.86 ml) was added triphenylphosphine (207 mg) and stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo, and the residue was purified with silica gel column chromatography to give methyl 4′-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate (142 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417060B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-523a535b547247b7bd71b4ada36b7b3d |
| Source note | uspto-grants-2008_08 |