反应详情

To a solution of methyl 4′-(2-hydroxyethoxy)-3-(isopropylthio)-4-biphenylcarboxylate (124 mg) and tetrabromomethane (285 mg) in tetrahydrofuran (1.86 ml) was added triphenylphosphine (207 mg) and stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo, and the residue was purified with silica gel column chromatography to give methyl 4′-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate (142 mg).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue was purified with silica gel column chromatography