Ethyl Acetate → HCID 69447078, compound

Participants

Reaction Steps

A solution of (R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-1-methyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester (258 mg) in 1 ml 4M HCl/dioxane was stirred 18 h at rt. The reaction mixture was portionned between AcOEt and 1M NaOH/ice. The organic layers were washed with brine, dried over magnesium sulfate and evaporated to deliver a white residue (115 mg) of the title compound. MS: 354.3 (M+H)+

Provenance & Evidence