Ethyl Acetate → HCID 69447078, compound

HRID 2220497Notes

Reaction equation

HRID 2220497 reaction equation
C(OC([N:8]1[C@@H:15]([C:16](=[O:32])[NH:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]3=[O:30])=[CH:20][C:19]=2[F:31])[C:14]2[CH:13]=[N:12][N:11]([CH3:33])[C:10]=2[CH2:9]1)=O)(C)(C)C.CCOC(C)=O>Cl.O1CCOCC1>[F:31][C:19]1[CH:20]=[C:21]([N:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]2=[O:30])[CH:22]=[CH:23][C:18]=1[NH:17][C:16]([C@H:15]1[C:14]2[CH:13]=[N:12][N:11]([CH3:33])[C:10]=2[CH2:9][NH:8]1)=[O:32]

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 69109321HCID 69109321, compound

Product 1

HCID 69447078HCID 69447078, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of (R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-1-methyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester (258 mg) in 1 ml 4M HCl/dioxane was stirred 18 h at rt. The reaction mixture was portionned between AcOEt and 1M NaOH/ice. The organic layers were washed with brine, dried over magnesium sulfate and evaporated to deliver a white residue (115 mg) of the title compound. MS: 354.3 (M+H)+

Workup

  1. washThe organic layers were washed with brine
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-fa89c6004a6a459786342c3751445cc5
Source dataset
uspto-grants-2008_08
Patent number
US07417144B2

Reaction notes

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