Hydrochloric Acid → HCID 178513285, compound

HRID 2220592Notes

Reaction equation

HRID 2220592 reaction equation
ONC([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:12][C:13]3[CH:19]=[C:18]([C:20]([NH:22][OH:23])=[NH:21])[CH:17]=[CH:16][C:14]=3[CH:15]=2)=[CH:7][CH:6]=1)=N.Cl>>[OH:23][NH:22][C:20]([C:10]1[CH:9]=[C:8]([C:11]2[O:12][C:13]3[CH:19]=[C:18]([C:20]([NH:22][OH:23])=[NH:21])[CH:17]=[CH:16][C:14]=3[CH:15]=2)[CH:7]=[CH:6][CH:5]=1)=[NH:21]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178513256HCID 178513256, compound

Product 1

HCID 178513285HCID 178513285, compound

Procedure

2-(4-(N-Hydroxycarbamimidoyl)phenyl)-N-hydroxybenzofuran-6-carboxamidine (181) White solid (0.78 g, 83%): mp 210° C. (dec) (aq HCl). 1H NMR (DMSO-d6) δ10.00-8.50 (br m, 6H), 8.19 (d, J=8.2 Hz, 2H), 8.15 (s, 1H), 7.95 (s, 1H), 7.94 (d, J=8.2 Hz, 2H), 7.88 (s, 1H), 7.69 (dd, J=8.2, 1.7 Hz, 1H). HPLC (method A) tR 4.33 min (100.0 area %). Anal. (C16H14N4O3.2HCl.1.2H2O) C, H, N, Cl.

Sources & evidence

ORD record
ord-ca8dac36d7f7486c851b27e4343712b0
Source dataset
uspto-grants-2008_08
Patent number
US07417158B2

Reaction notes

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