Hydrochloric Acid → HCID 23134383, compound

HRID 2220638Notes

Reaction equation

HRID 2220638 reaction equation
[OH-].[Na+].C[O:4][C:5](=[O:28])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]([CH3:19])=[CH:17][C:16]([O:20][CH2:21][CH2:22][O:23]C(=O)C)=[CH:15][C:14]=2[CH3:27])=[CH:9][CH:8]=1.Cl>C(O)C>[OH:23][CH2:22][CH2:21][O:20][C:16]1[CH:17]=[C:18]([CH3:19])[C:13]([C:10]2[CH:11]=[CH:12][C:7]([CH2:6][C:5]([OH:28])=[O:4])=[CH:8][CH:9]=2)=[C:14]([CH3:27])[CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 90950016HCID 90950016, compound

Product 1

HCID 23134383HCID 23134383, compoundYield 109%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

A 2 mol/L aqueous solution of sodium hydroxide (2 mL) was added to a solution of methyl[4′-(2-acetoxyethoxy)-2′,6′-dimethylbiphenyl-4-yl]acetate (0.318 g) in ethanol (10 mL), and the mixture was stirred at 40° C. for 1 hr. To the reaction mixture was added 2 mol/L hydrochloric acid (2 mL), and the solvent was evaporated under reduced pressure. Water and ethyl acetate were added to the residue. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.292 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionWater and ethyl acetate were added to the residue
  3. customThe organic layer was separated
  4. washwashed with water and brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c0e13605fdf741c494588ee7de9cca6b
Source dataset
uspto-grants-2008_08
Patent number
US07417169B2

Reaction notes

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