HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 69200435, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 90901336 | HCID 90901336 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69200435 | HCID 69200435 | 94.1% |
Reaction Steps
A mixture of ethyl(4′-{2-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethylamino]-ethoxy}biphenyl-4-yloxy)acetate (60 mg) and a 2 mol/L aqueous solution of sodium hydroxide (0.138 mL) in tetrahydrofuran (5 mL) was stirred at room temperature for 30 minutes. To the mixture was added 2 mol/L hydrochloric acid (0.138 mL), and the solvent was evaporated under reduced pressure. The residue was washed with water to afford the title compound (0.054 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07417169B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-8258f7f2970845fda8f6dfd2f5d9f701 |
| Source note | uspto-grants-2008_08 |