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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2220651Generated: November 2, 2026

Hydrochloric Acid → HCID 69200435, compound

https://huagongshe.com/reaction/2220651

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 90901336HCID 90901336—
SolventTetrahydrofuranHCID 8028—
ProductHCID 69200435HCID 6920043594.1%

Reaction Steps

A mixture of ethyl(4′-{2-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethylamino]-ethoxy}biphenyl-4-yloxy)acetate (60 mg) and a 2 mol/L aqueous solution of sodium hydroxide (0.138 mL) in tetrahydrofuran (5 mL) was stirred at room temperature for 30 minutes. To the mixture was added 2 mol/L hydrochloric acid (0.138 mL), and the solvent was evaporated under reduced pressure. The residue was washed with water to afford the title compound (0.054 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07417169B2
Source datasetuspto-grants-2008_08
ORD IDord-8258f7f2970845fda8f6dfd2f5d9f701
Source noteuspto-grants-2008_08