Hydrochloric Acid → HCID 69200435, compound

HRID 2220651Notes

Reaction equation

HRID 2220651 reaction equation
C([O:3][C:4](=[O:46])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C@@H:23]([CH3:45])[C@@H:24]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[C:28]([NH:40][S:41]([CH3:44])(=[O:43])=[O:42])[CH:27]=3)[OH:25])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+].Cl>O1CCCC1>[CH2:33]([O:32][C:29]1[CH:30]=[CH:31][C:26]([C@@H:24]([OH:25])[C@@H:23]([NH:22][CH2:21][CH2:20][O:19][C:16]2[CH:17]=[CH:18][C:13]([C:10]3[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:46])=[O:3])=[CH:8][CH:9]=3)=[CH:14][CH:15]=2)[CH3:45])=[CH:27][C:28]=1[NH:40][S:41]([CH3:44])(=[O:42])=[O:43])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 90901336HCID 90901336, compound

Product 1

HCID 69200435HCID 69200435, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of ethyl(4′-{2-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethylamino]-ethoxy}biphenyl-4-yloxy)acetate (60 mg) and a 2 mol/L aqueous solution of sodium hydroxide (0.138 mL) in tetrahydrofuran (5 mL) was stirred at room temperature for 30 minutes. To the mixture was added 2 mol/L hydrochloric acid (0.138 mL), and the solvent was evaporated under reduced pressure. The residue was washed with water to afford the title compound (0.054 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with water

Sources & evidence

ORD record
ord-8258f7f2970845fda8f6dfd2f5d9f701
Source dataset
uspto-grants-2008_08
Patent number
US07417169B2

Reaction notes

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