2-Naphthalenecarboxaldehyde → HCID 9921547, compound

HRID 2220691Notes

Reaction equation

HRID 2220691 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=O.[CH3:13][N:14]1[CH2:18][CH2:17][CH2:16][CH:15]1[CH2:19][CH2:20][NH2:21].[Na]>ClCCl>[CH3:13][N:14]1[CH2:18][CH2:17][CH2:16][CH:15]1[CH2:19][CH2:20][NH:21][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1

Participants

5

Reactant 3

HCID 62012-NaphthalenecarboxaldehydeHCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 5360545Sodium

Product 1

HCID 9921547HCID 9921547, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Experimental condition analogous to Example 1, from 2-naphthalencarboxaldehyde 0.15 g (1 mmol), 2-(1-methyl-pyrrolidin-2-yl)-ethylamine 0.14 g (1.1 mmol), and sodium triacethoxyborohydride 0.31 g (1.5 mmol), in 10 mL dichloromethane. The crude material is 110 mg pale yellow oil.

Sources & evidence

ORD record
ord-19db3e749d5a4368b91a9eac03a710b1
Source dataset
uspto-grants-2008_08
Patent number
US07417062B2

Reaction notes

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