Dichloromethane → HCID 58622191, compound

HRID 2220705Notes

Reaction equation

HRID 2220705 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][N:14]([C:27]1[CH:28]=[C:29]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:30]=[CH:31][CH:32]=1)[C:15](=[O:26])[C:16]1[CH:21]=[CH:20][C:19]([O:22]C)=[C:18]([O:24][CH3:25])[CH:17]=1)=O)(C)(C)C.F[C:40]([F:45])([F:44])C(O)=O.ClCCl>C(#N)C>[C:29]1([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:30]=[CH:31][CH:32]=[C:27]([N:14]([CH2:13][C@@H:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)[C:15](=[O:26])[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH:40]([F:44])[F:45])=[C:18]([O:24][CH3:25])[CH:17]=2)[CH:28]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acid2×HCID 58622270HCID 58622270, compound

Product 1

HCID 58622191HCID 58622191, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Experimental condition analogous to Example 1, from 1 g (1.94 mmol) of 2-(S)-{[biphenyl-3-yl-(3,4-dimethoxy-benzoyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester, 25 mL of trifluoroacetic acid and 100 mL of dichloromethane. Gave 0.75 gram of white semi solid: LC-MSD, m/z for: C26H26F2N2O3 [M+H]: 452.2. LC retention time on HPLC, C18 column gradient 20-95% acetonitrile with 0.1% TFA in 7 minutes: 3.54.

Workup

  1. customGave 0.75 gram of white semi solid

Sources & evidence

ORD record
ord-d9f18d78a408453f98fd0b787988ced2
Source dataset
uspto-grants-2008_08
Patent number
US07417062B2

Reaction notes

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