Potassium Acetate → 61479-36-5

HRID 2220745Notes

Reaction equation

HRID 2220745 reaction equation
CC1C=CC(S(O[N:12]=[C:13]2[CH2:22][CH2:21][CH2:20][C:19]3[N:18]=[CH:17][CH:16]=[CH:15][C:14]2=3)(=O)=O)=CC=1.C([O-])(=[O:25])C.[K+]>CCO.O>[N:18]1[C:19]2[CH2:20][CH2:21][CH2:22][C:13](=[O:25])[NH:12][C:14]=2[CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 517044Potassium AcetateHCID 85948845HCID 85948845, compound

Product 1

HCID 1228303261479-36-5

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 1.0 eq of 95 and 2.3 eq of potassium acetate in 70 mL of EtOH and 140 mL of H2O was refluxed for 17 hrs. After cooling to rt and rotary evaporation of the EtOH, the solution was made alkaline with 10 N NaOH. The mixture was extracted with chloroform (3×50 mL). The combined organic extracts were dried over MgSO4 and vacuum filtered. The filtrate was rotary evaporated and dried under vacuum to yield 96.

Workup

  1. temperaturewas refluxed for 17 hrs
  2. customrotary evaporation of the EtOH
  3. extractionThe mixture was extracted with chloroform (3×50 mL)
  4. dry with materialThe combined organic extracts were dried over MgSO4 and vacuum
  5. filtrationfiltered
  6. customThe filtrate was rotary evaporated
  7. customdried under vacuum

Sources & evidence

ORD record
ord-1274ecf09d6440cdb06d900122c2621f
Source dataset
uspto-grants-2008_08
Patent number
US07417152B2

Reaction notes

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