HCID 57747299, compound → 4-(6-(4-(Pyridin-4-yl)phenoxy)-7H-purin-2-ylamino)benzonitrile

HRID 222076Notes

Reaction equation

HRID 222076 reaction equation
COC1C=CC(C[N:8]2[C:16]3[C:11](=[N:12][C:13]([NH:30][C:31]4[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[CH:33][CH:32]=4)=[N:14][C:15]=3[O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=4)=[CH:20][CH:19]=3)[N:10]=[CH:9]2)=CC=1>C(O)(C(F)(F)F)=O>[N:27]1[CH:28]=[CH:29][C:24]([C:21]2[CH:22]=[CH:23][C:18]([O:17][C:15]3[N:14]=[C:13]([NH:30][C:31]4[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[CH:33][CH:32]=4)[N:12]=[C:11]4[C:16]=3[NH:8][CH:9]=[N:10]4)=[CH:19][CH:20]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 1

HCID 57747299HCID 57747299, compound

Product 1

HCID 577474354-(6-(4-(Pyridin-4-yl)phenoxy)-7H-purin-2-ylamino)benzonitrile

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 4-(7-(4-methoxybenzyl)-6-(4-(pyridin-4-yl)phenoxy)-7H-purin-2-ylamino)benzonitrile (38 mg, 0.07 mmol) in TFA (0.5 mL) was heated at 60° C. overnight. The desired product was precipitated with EtOAc (2 mL) and collected by filtration. NMR (DMSO-d6): 9.98 (s, 1H), 8.95 (d, 2H), 8.38 (d, 2H), 8.35 (d, 2H), 8.20 (d, 2H), 7.76 (d, 2H), 7.63 (d, 2H), 7.53 (d, 2H).

Workup

  1. customThe desired product was precipitated with EtOAc (2 mL)
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-07b3f960f981430392c5f6774bdac784
Source dataset
uspto-grants-2012_06
Patent number
US08207178B2

Reaction notes

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