HRID2220761

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1048

Pyrazole

C3H4N2

HCID6454398

2-Pyridone hydrazone dihydrochloride

C5H9Cl2N3

HCID59223396

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)NCCC2CCN(c3ccncc3)CC2)nn(-c2ccccn2)c1NC(=O)c1ccccc1Cl

HCID59773605

未命名化合物

PROCEDURE

实验过程

The pyrazole acid, prepared as described in Procedure 8 using 5-amino-4-methyl-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester (prepared as described in Procedure 41 using 3-cyano-3-methyl-2-oxopropanoic acid ethyl ester (U.S. Pat. No. 4,652,669) and 2-hydrazinopyridine dihydrochloride (Aldrich, H1,710-4)) in place of compound 20, was coupled to 2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)ethylamine (prepared as described in Procedure 14) using the method of Procedure 10.

WORKUP

后处理

customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-da1ae0b6873a411083eee8bc988f168a
来源数据集: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07417152B2
来源说明: uspto-grants-2008_08

反应 SMILES

N1C=CC=N1.C(OC(C1C(C)=C(N)N([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)N=1)=O)C.C(OC(=O)C(=O)C(C#N)C)C.Cl.Cl.N([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=1)N.NC1N(C(OC(C)(C)C)=O)N=C(C(OC)=O)C=1.O=[C:63]1NC2C=CC=CC=2C(C2C=CC=CC=2)=N[CH:64]1[NH:80][C:81]([C:83]1[C:87]([CH3:88])=[C:86]([NH:89][C:90](=[O:98])[C:91]2[CH:96]=[CH:95][CH:94]=[CH:93][C:92]=2[Cl:97])[N:85]([C:99]2[CH:104]=[CH:103][CH:102]=[CH:101][N:100]=2)[N:84]=1)=[O:82]>>[N:40]1([C:22]2[CH:23]=[CH:18][N:19]=[CH:20][CH:21]=2)[CH2:41][CH2:42][CH:43]([CH2:63][CH2:64][NH:80][C:81]([C:83]2[C:87]([CH3:88])=[C:86]([NH:89][C:90](=[O:98])[C:91]3[CH:96]=[CH:95][CH:94]=[CH:93][C:92]=3[Cl:97])[N:85]([C:99]3[CH:104]=[CH:103][CH:102]=[CH:101][N:100]=3)[N:84]=2)=[O:82])[CH2:44][CH2:39]1