tert-Butoxycarbonyl-D-leucine → HCID 59709937, compound

HRID 2220812Notes

Reaction equation

HRID 2220812 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:14]([OH:16])=O)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH:18]1([CH2:21][C@@H:22]([C:24]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:25])[NH2:23])[CH2:20][CH2:19]1>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:14]([NH:23][C@H:22]([C:24]([O:26][CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)=[O:25])[CH2:21][CH:18]1[CH2:20][CH2:19]1)=[O:16])[CH2:10][CH:11]([CH3:12])[CH3:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 637604tert-Butoxycarbonyl-D-leucineHCID 68801862HCID 68801862, compound

Product 1

HCID 59709937HCID 59709937, compound

Procedure

N-(tert-Butoxycarbonyl)-D-leucine (540 mg, 2.32 mmol) and benzyl 3-cyclopropyl-L-alaninate hydrochloride (Example 3A, 490 mg, 1.93 mmol) are reacted by general procedure 6. The crude product is purified by preparative HPLC, (method 16), resulting in a quantitive yield of the product.

Workup

  1. customThe crude product is purified by preparative HPLC, (method 16),
  2. customresulting in a quantitive yield of the product

Sources & evidence

ORD record
ord-2babaaee8faa4a2e924b9afd581c7aec
Source dataset
uspto-grants-2008_05
Patent number
US07368424B2

Reaction notes

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