反应详情

(2-Methoxy-5-morpholin-4-yl-phenyl)-thiourea (5.0 g, 19 mmol) in chloroform (130 ml) are treated with bromine (960 μl) and the mixture refluxed for 18 hours. After removal of the volatile components in vacuo, the product is recrystallized from THF (2.8 g, 57%). MS: m/e=266 (M+).

1. temperaturethe mixture refluxed for 18 hours
2. customAfter removal of the volatile components in vacuo
3. customthe product is recrystallized from THF (2.8 g, 57%)