Bromine → 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

HRID 2220829Notes

Reaction equation

HRID 2220829 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:5][C:4]=1[NH:15][C:16]([NH2:18])=[S:17].BrBr>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]2[N:15]=[C:16]([NH2:18])[S:17][C:5]=2[C:6]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 220157331-(2-Methoxy-5-morpholinophenyl)thiourea

Product 1

HCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

(2-Methoxy-5-morpholin-4-yl-phenyl)-thiourea (5.0 g, 19 mmol) in chloroform (130 ml) are treated with bromine (960 μl) and the mixture refluxed for 18 hours. After removal of the volatile components in vacuo, the product is recrystallized from THF (2.8 g, 57%). MS: m/e=266 (M+).

Workup

  1. temperaturethe mixture refluxed for 18 hours
  2. customAfter removal of the volatile components in vacuo
  3. customthe product is recrystallized from THF (2.8 g, 57%)

Sources & evidence

ORD record
ord-e786addbec634e43abf164a5c72877ee
Source dataset
uspto-grants-2008_05
Patent number
US07368446B2

Reaction notes

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