反应详情

To a mixture of 4-(4-(4-bromo-2,6-dimethylphenylthio)-6-methyl-5-nitropyrimidin-2-ylamino)benzonitrile (50 mmol) in DMF (300 ml) is added tert-butoxybis(dimethylamino) methane (60 mmol) over 15 minutes. The mixture is stirred at room temperature overnight. DMF is partially removed. The residue is washed with water and extracted with ethyl acetate (×3). The combined organic layers are washed with brine, dried (MgSO4) and concentrated to dryness to give the desired product which is used in next step without further purification.

1. customDMF is partially removed
2. washThe residue is washed with water
3. extractionextracted with ethyl acetate (×3)
4. washThe combined organic layers are washed with brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated to dryness