Carbodiimide → HCID 60208255, compound

HRID 2221021Notes

Reaction equation

HRID 2221021 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][N:11]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][C:16]([NH:22][C:23]([NH:25][C@H:26]3[CH2:31][C@H:30]4[CH2:32][C@H:28]([C:29]4([CH3:34])[CH3:33])[C@@H:27]3[CH3:35])=S)=[CH:17][CH:18]=2)[N:13]=[CH:12]1.N=C=N>C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][N:11]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][C:16]([N:22]=[C:23]=[N:25][C@H:26]3[CH2:31][C@H:30]4[CH2:32][C@H:28]([C:29]4([CH3:34])[CH3:33])[C@@H:27]3[CH3:35])=[CH:17][CH:18]=2)[N:13]=[CH:12]1

Participants

4

Reactant 2

HCID 160435CarbodiimideHCID 60208256HCID 60208256, compound

Product 1

HCID 60208255HCID 60208255, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-{3-[2-(2,4-dichlorophenyl)ethyl]-4-oxo-3,4-dihydro-7-quinazolinyl}-N′-[(1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]thiourea was gently stirred with Argonaut PS-Carbodiimide (1.5 eq) for 15 hours in THF. The resin was filtered off and the solution of carbodiimide B was diluted to a known volume to give a solution of known molarity.

Workup

  1. filtrationThe resin was filtered off
  2. additionthe solution of carbodiimide B was diluted to a known volume
  3. customto give a solution of known molarity

Sources & evidence

ORD record
ord-a8894b8b7e9640358bbd66d35e7238a9
Source dataset
uspto-grants-2008_05
Patent number
US07368453B2

Reaction notes

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