Trifluoroacetic acid → HCID 59710625, compound

HRID 2221125Notes

Reaction equation

HRID 2221125 reaction equation
[F:1][CH2:2][C:3]1[CH:33]=[CH:32][C:6]([C:7]([NH:9][CH2:10][CH2:11][S:12]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[O:8])=[CH:5][CH:4]=1.C(O)(C(F)(F)F)=O>O>[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][CH2:10][CH2:11][SH:12])=[O:8])=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59710633HCID 59710633, compound

Product 1

HCID 59710625HCID 59710625, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1.4 mg (3.0 μmol) of 4-fluoromethyl-N-[2-(tritylsulphanyl)ethyl]benzamide was added 50 μl of TFA/TIS/H2O(95:2.5:2.5) mixture. The flask was swirled gently for 5 minutes and then concentrated in vacuo. LC-MS analysis (column Phenomenex Luna 3 μm C18(2) 50×2.00 mm; solvents: A=water/0.1% HCOOH and B=acetonitrile/0.1% HCOOH; gradient 5-60% B over 10 min; flow 0.3 ml/min, UV detection at 214 and 254 nm, ESI-MS) gave a peak (tR 6.8 min) with m/z at 214 corresponding to MH+.

Workup

  1. concentrationconcentrated in vacuo
  2. waitgradient 5-60% B over 10 min
  3. customgave a peak (tR 6.8 min) with m/z at 214 corresponding to MH+

Sources & evidence

ORD record
ord-de1074ee6545482d8318174b209f9ae4
Source dataset
uspto-grants-2008_05
Patent number
US07368474B2

Reaction notes

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