反应详情

Ethyl 2-{1-benzyl-5-[4-(trifluoromethyl)phenyl]-1H-indol-3-yl}-2-oxoacetate was prepared from 1-Benzyl-5-[4-(trifluoromethyl)phenyl]-1H-indole (0.307 g, 0.874 mmol), oxalyl chloride (0.29 mL, 3.3 mmol), and ethanol (3 mL) following the procedure described in Step 3 of Example 1. The compound was purified by flash chromatography using 10-20% ethyl acetate in hexane as an eluant and dried for 20 minutes at 60° C. to give a light yellow solid (0.249 g, 63%), mp: 99-100° C. 1HNMR (200 MHz, DMSO-d6): δ 8.8 (s, 1H), 8.5 (s, 1H), 7.6-7.95 (m, 6H), 7.25-7.4 (m, 5H), 5.65 (s, 2H), 4.35 (q, 2H, J=7.7 Hz), and 1.35 ppm (t, 3H, J=7.7 Hz).

1. customThe compound was purified by flash chromatography
2. customdried for 20 minutes at 60° C.