Potassium Hydroxide → HCID 24989583, compound

HRID 222124Notes

Reaction equation

HRID 222124 reaction equation
C([O:3][C:4]([C:6]1[C:18]2[CH2:17][CH2:16][C:15]3[CH:14]=[N:13][CH:12]=[CH:11][C:10]=3[C:9]=2[NH:8][CH:7]=1)=[O:5])C.[OH-].[K+]>C(O)C>[NH:8]1[C:9]2[C:10]3[CH:11]=[CH:12][N:13]=[CH:14][C:15]=3[CH2:16][CH2:17][C:18]=2[C:6]([C:4]([OH:5])=[O:3])=[CH:7]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68707167HCID 68707167, compound

Product 1

HCID 24989583HCID 24989583, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4,5-dihydro-1H-pyrrolo[2,3-f]isoquinoline-3-carboxylic acid ethyl ester E2 (0.165 mmol) in ethanol (3 mL), 2N KOH (20 eq) was added and the mixture was heated at 60° for 4 h. After solvent removal the solution was neutralized with 1N HCl and the precipitate was filtered and dried, providing the title compound in 56% yield.

Workup

  1. temperaturethe mixture was heated at 60° for 4 h
  2. customAfter solvent removal the solution
  3. filtrationthe precipitate was filtered
  4. customdried

Sources & evidence

ORD record
ord-7d77fffb8b124775a930470699263276
Source dataset
uspto-grants-2012_06
Patent number
US08207180B2

Reaction notes

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