Caprolactam → HCID 69215353, compound

HRID 2221365Notes

Reaction equation

HRID 2221365 reaction equation
[N:1]([CH2:4][Si:5]([O:8][CH3:9])([CH3:7])[CH3:6])=[C:2]=[O:3].[C:10]1(=[O:17])[NH:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>O1CCOCC1>[CH3:9][O:8][Si:5]([CH2:4][NH:1][C:2]([N:16]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:17])=[O:3])([CH3:7])[CH3:6]

Participants

4

Reactant 2

HCID 7768CaprolactamHCID 71360899(Isocyanatomethyl)(methoxy)dimethylsilane

Product 1

HCID 69215353HCID 69215353, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 1.45 g of (isocyanatomethyl)methoxy-dimethylsilane and 1.13 g of ε-caprolactam in 25 ml of anhydrous dioxane was heated at reflux with stirring for 4 h. The solvent was subsequently removed under reduced pressure. This gave hexahydro-N-[(methoxydimethylsilyl)methyl]-2-oxo-1H-azepine-1-carboxamide in quantitative yield with a purity of >90% (analysis by 1H NMR).

Workup

  1. temperatureat reflux
  2. customThe solvent was subsequently removed under reduced pressure

Sources & evidence

ORD record
ord-b7d0c32a4fd044ec85c1ae377a20a719
Source dataset
uspto-grants-2008_05
Patent number
US07368586B2

Reaction notes

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