Triethylamine → HCID 178526855, compound

HRID 2221410Notes

Reaction equation

HRID 2221410 reaction equation
[Cl:1][C:2]1[NH:3][C:4](I)=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.C(N(CC)CC)C.[H][H]>C(O)C.[C].[Pd]>[Cl:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 178418361HCID 178418361, compoundHCID 178526897HCID 178526897, compound

Product 1

HCID 178526855HCID 178526855, compoundYield 83.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

2-Chloro-5-iodo-4-nitroimidazole (545 mg) was dissolved in ethanol (10 ml), then triethylamine (840 μl) and 10% palladium-carbon (54 mg) were added, the reaction mixture was subjected to hydrogenation at hydrogen pressure of 4 kg/cm2 by use of Pearl reduction equipment, there was obtained 2-chloro-4-nitroimidazole (246 mg, yield: 83.4%) as colorless solid matter.

Sources & evidence

ORD record
ord-d315afe3ef8c4944945f1e5188ce9a20
Source dataset
uspto-grants-2008_05
Patent number
US07368579B2

Reaction notes

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