O-Methylhydroxylamine hydrochloride → HCID 10334942, compound

HRID 2221487Notes

Reaction equation

HRID 2221487 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][N:7]2[C:11]3[CH:12]=[N:13][C:14]([C:16](O)=[O:17])=[CH:15][C:10]=3[N:9]=[CH:8]2)=[CH:4][CH:3]=1.Cl.[CH3:22][O:23][NH2:24]>>[F:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][N:7]2[C:11]3[CH:12]=[N:13][C:14]([C:16]([NH:24][O:23][CH3:22])=[O:17])=[CH:15][C:10]=3[N:9]=[CH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 218922273-(4-Fluorobenzyl)-3H-imidazo[4,5-c]pyridine-6-carboxylic acid

Product 1

HCID 10334942HCID 10334942, compound

Procedure

The title compound was prepared by coupling of 3-(4-fluorobenzyl)-3H-imidazo[4,5-c]pyridine-6-carboxylic acid and N-methoxyamine hydrochloride under the same conditions as those in step (c) of example 1. 1H NMR (300 MHz, MeOH-d4) δ: 8.71 (s, 1H), 8.53 (s, 1H), 8.32 (s, 1H), 7.36-7.33 (m, 2H), 7.07-7.05 (m, 2H), 5.57 (s, 2H), 3.75 (s, 3H). LCMS (API-ES, M+H+): 301.1. HRMS calcd for C15H14FN4O2 (M+H) 301.1 101, found 301.1105. HPLC: >84% purity.

Sources & evidence

ORD record
ord-c500b61654a840a69a5ce46a6cabec6e
Source dataset
uspto-grants-2008_05
Patent number
US07368571B2

Reaction notes

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