反应详情

To a solution of 4-{[2-(2-furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxybenzaldehyde (9.70 g) in tetrahydrofuran (100 mL)-ethanol (50 mL) was gradually added sodium borohydride (1.23 g) at room temperature. After stirring at room temperature for 30 min., water was added to the reaction mixture and the precipitated crystals were collected by filtration to give (4-{[2-(2-furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxyphenyl)methanol as pale-brown crystals (8.40 g, yield 86%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 117-118° C.

1. customat room temperature
2. filtrationthe precipitated crystals were collected by filtration