反应详情

To a solution of 3-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-4-methoxybenzaldehyde (14.0 g) in tetrahydrofuran (100 mL)-ethanol (30 mL) was gradually added sodium borohydride (1.69 g) at 0° C. After stirring at room temperature for 2 hrs., water was added to the reaction mixture and the precipitated crystals were collected by filtration to give (3-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-4-methoxyphenyl)methanol as pale-yellow crystals (12.87 g, yield 91%). Recrystallization from ethyl acetate-hexane gave pale-yellow prism crystals. melting point: 145-146° C.

1. customat 0° C
2. filtrationthe precipitated crystals were collected by filtration