HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2221519Generated: October 27, 2026
Dimethylformamide → 4-{[2-(2-Furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-(methoxymethoxy)benzaldehyde
https://huagongshe.com/reaction/2221519
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 12397043 | HCID 12397043 | — |
| Reactant | 4-(Chloromethyl)-2-(furan-2-yl)-5-methyl-1,3-oxazole | HCID 22344582 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-{[2-(2-Furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-(methoxymethoxy)benzaldehyde | HCID 23076616 | 78% |
Reaction Steps
A mixture of 4-chloromethyl-2-(2-furyl)-5-methyl-1,3-oxazole (13.12 g), 4-hydroxy-3-methoxymethoxybenzaldehyde (11.0 g), potassium carbonate (8.35 g) and N,N-dimethylformamide (200 mL) was stirred at 90° C. for 3 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration and dried to give 4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-(methoxymethoxy)benzaldehyde as pale-brown crystals (16.11 g, yield 78%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 102-103° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07368578B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-98f09afa15c842818aea093b00466ed3 |
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| Source note | uspto-grants-2008_05 |
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