反应详情

温度

90 °C

A mixture of 4-chloromethyl-2-(2-furyl)-5-methyl-1,3-oxazole (13.12 g), 4-hydroxy-3-methoxymethoxybenzaldehyde (11.0 g), potassium carbonate (8.35 g) and N,N-dimethylformamide (200 mL) was stirred at 90° C. for 3 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration and dried to give 4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-(methoxymethoxy)benzaldehyde as pale-brown crystals (16.11 g, yield 78%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 102-103° C.

1. filtrationthe precipitated crystals were collected by filtration
2. customdried