反应详情

To a solution of 4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-methoxybenzaldehyde (3.00 g) in tetrahydrofuran (30 mL)-ethanol (10 mL) was gradually added sodium borohydride (0.36 g) at 0° C. After stirring at room temperature for 1 hr., water was added to the reaction mixture and the precipitated crystals were collected by filtration to give (4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-methoxyphenyl)methanol as colorless crystals (2.91 g, yield 96%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 117-118° C.

1. customat 0° C
2. filtrationthe precipitated crystals were collected by filtration