反应详情

To a solution of 3-methoxy-4-[(5-methyl-2-piperidin-1-yl-1,3-thiazol-4-yl)methoxy]benzaldehyde (0.50 g) in tetrahydrofuran (5 mL)-ethanol (5 mL) was gradually added sodium borohydride (0.05 g) at room temperature. After stirring for 1 hr, water was added to the reaction mixture and the precipitated crystals were collected by filtration to give {3-methoxy-4-[(5-methyl-2-piperidin-1-yl-1,3-thiazol-4-yl)methoxy]phenyl}methanol as colorless crystals (0.44 g, yield 90%). melting point: 92-93° C.

1. customat room temperature
2. filtrationthe precipitated crystals were collected by filtration