反应详情

To a solution of 3-methoxy-4-[(1-methyl-4-phenyl-1H-imidazol-2-yl)methoxy]benzaldehyde (1.37 g) in tetrahydrofuran (50 mL)-ethanol (10 mL) was gradually added sodium borohydride (0.16 g) at room temperature, and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture and the precipitated crystals were collected by filtration to give {3-methoxy-4-[(1-methyl-4-phenyl-1H-imidazol-2-yl)methoxy]phenyl}methanol as colorless crystals (1.15 g, yield 85%). Recrystallization from ethyl acetate-hexane gave colorless needle crystals. melting point: 126-127° C.

1. customat room temperature
2. filtrationthe precipitated crystals were collected by filtration