反应详情

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

1. temperaturewas refluxed for 5 hours
2. customAfter the reaction
3. custommost of the acetonitrile was removed by distillation and water
4. additionwas added to the residue
5. customAs the solid product was separated
6. filtrationit was collected by filtration
7. customThe crude material was recrystallized from ethanol