反应详情

A mixture of 4-(4-chloromethyl-5-methyl-1,3-thiazol-2-yl)morpholine (1.00 g), triphenylphosphine (1.13 g) and acetonitrile (50 mL) was heated under reflux for 15 hrs. After concentration of the reaction mixture, the precipitated crystals were washed with acetonitrile and diethyl ether to give (5-methyl-2-morpholin-4-yl-1,3-thiazol-4-yl)triphenylphosphonium chloride as pale-yellow crystals (1.93 g, yield 91%). Recrystallization from acetonitrile-diethyl ether gave colorless prism crystals. melting point: 242-243° C.

1. temperaturewas heated
2. temperatureunder reflux for 15 hrs
3. washAfter concentration of the reaction mixture, the precipitated crystals were washed with acetonitrile and diethyl ether