反应详情

To a mixture of {3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazol-4-yl}acetonitrile (0.86 g) and ethanol (30 mL) was added 2N aqueous sodium hydroxide solution (30 mL), and the mixture was heated under reflux for 6 hrs. The reaction mixture was neutralized by adding 1N hydrochloric acid and water; and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to give {3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazol-4-yl}acetic acid as yellow crystals (0.80 g, yield 91%). Recrystallization from ethyl acetate-hexane gave yellow prism crystals. melting point: 179-180° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 6 hrs
3. extractionand the mixture was extracted with ethyl acetate
4. washThe organic layer was washed with saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated