Hydrochloric Acid → HCID 178440050, compound

HRID 2221666Notes

Reaction equation

HRID 2221666 reaction equation
[CH:1]([C:4]1[S:5][CH:6]=[C:7](/[CH:9]=[CH:10]/[C:11]2[C:12]([O:22]COC)=[N:13][N:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)[N:8]=1)([CH3:3])[CH3:2].[ClH:26]>CO>[ClH:26].[CH:1]([C:4]1[S:5][CH:6]=[C:7](/[CH:9]=[CH:10]/[C:11]2[C:12]([OH:22])=[N:13][N:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:15]=2)[N:8]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23076600HCID 23076600, compound

Product 1

HCID 178440050HCID 178440050, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-isopropyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (1.47 g) in methanol (20 mL) was added concentrated hydrochloric acid (0.5 mL) at room temperature, and the mixture was stirred at room temperature for 20 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-hexane to give 4-[(E)-2-(2-isopropyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol hydrochloride (1.43 g, yield 99%) as pale-yellow crystals. melting point: 137-139° C.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate-hexane

Sources & evidence

ORD record
ord-01cbefd6083c4187a76f39ff429ed7c4
Source dataset
uspto-grants-2008_05
Patent number
US07368578B2

Reaction notes

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