Hydrochloric Acid → HCID 178440048, compound

HRID 2221669Notes

Reaction equation

[CH:1]([C:4]1[O:5][CH:6]=[C:7](/[CH:9]=[CH:10]/[C:11]2[C:12]([O:22]COC)=[N:13][N:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)[N:8]=1)([CH3:3])[CH3:2].[ClH:26]>CO>[ClH:26].[CH:1]([C:4]1[O:5][CH:6]=[C:7](/[CH:9]=[CH:10]/[C:11]2[C:12]([OH:22])=[N:13][N:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:15]=2)[N:8]=1)([CH3:3])[CH3:2]

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of 2-isopropyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-oxazole (1.00 g) in methanol (12 mL) was added concentrated hydrochloric acid (0.52 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure, and the residue was washed with diethyl ether to give 4-[(E)-2-(2-isopropyl-1,3-oxazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol hydrochloride (0.95 g, yield 92%) as orange crystals. melting point: 205-209° C.

Workup

customThe reaction mixture was evaporated under reduced pressure
washthe residue was washed with diethyl ether

Sources & evidence

ORD record: ord-fb3e5cb360f249248b65f7b02a5c42ff
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07368578B2

Reaction notes

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