Hydrochloric Acid → HCID 178441602, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-tert-butyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-oxazole (2.15 g) in methanol (25 mL) was added concentrated hydrochloric acid (1.00 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure, and the residue was washed with diethyl ether to give 4-[(E)-2-(2-tert-butyl-1,3-oxazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol-hydrochloride (1.74 g, yield 83%) as orange crystals. melting point: 220-221° C.

Provenance & Evidence