Hydrochloric Acid → HCID 178441602, compound

HRID 2221671Notes

Reaction equation

[C:1]([C:5]1[O:6][CH:7]=[C:8](/[CH:10]=[CH:11]/[C:12]2[C:13]([O:23]COC)=[N:14][N:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:16]=2)[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:27]>CO>[ClH:27].[C:1]([C:5]1[O:6][CH:7]=[C:8](/[CH:10]=[CH:11]/[C:12]2[C:13]([OH:23])=[N:14][N:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:16]=2)[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of 2-tert-butyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-oxazole (2.15 g) in methanol (25 mL) was added concentrated hydrochloric acid (1.00 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure, and the residue was washed with diethyl ether to give 4-[(E)-2-(2-tert-butyl-1,3-oxazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol-hydrochloride (1.74 g, yield 83%) as orange crystals. melting point: 220-221° C.

Workup

customThe reaction mixture was evaporated under reduced pressure
washthe residue was washed with diethyl ether

Sources & evidence

ORD record: ord-8f84a112869c43e998cea270357ba4bd
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07368578B2

Reaction notes

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