反应详情

温度

50 °C

To a solution of 2-ethyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (4.49 g) in methanol (50 mL) was added concentrated hydrochloric acid (2.17 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure and the residue was washed with ethyl acetate-diethyl ether to give 4-[(E)-2-(2-ethyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol (4.18 g, yield 95%) as orange crystals. hydrochloride. melting point: 222-224° C.

1. customThe reaction mixture was evaporated under reduced pressure
2. washthe residue was washed with ethyl acetate-diethyl ether